SquameScan 850C Skin Angle Quality Tester

The stratum corneum (SC) is composed of highly organized and structured layers of dead cells, which are crucial for maintaining the water gradient between the upper layers of the skin. Many factors can interfere with the moisture barrier of the skin, which may cause dryness, irritation, or itching, thereby affecting the overall quality of the skin. External cosmetics can help repair and prevent damage to the skin barrier, enhance moisturizing effects, and reduce the severity of existing skin conditions.
Tape peeling technology has been established as a simple technique for sampling or evaluating the function of the epidermal stratum corneum (SC), and has been widely used in dermatology research. SC lipids, moisturizing factors, enzymes, cytokines, and growth factors were analyzed from these tape peels. These are typically used to evaluate skin condition and track the effectiveness of locally applied products. For most studies, it is necessary to determine the fixed angular mass for each tape peel, as all analytes are reported as a ratio to the collected SC amount, whether by weight determination or protein determination. This not only allows for comparison between samples, i.e. the amount of analyte per unit of SC protein, but also allows for correction of changes in analyte concentration caused by variations in SC depth.
SquameScan 850C Skin Angle Quality TesterIt is a convenient research tool for measuring the optical absorption of SC peels, and its absorption value is linearly proportional to protein content. This method has great value for researchers who use SC as a skin health indicator. Although the data distribution varies among different subject groups, regression analysis is always very similar and independent of age, skin moisture content, skin pH value, and different skin regions of the test subjects. The achieved correlation is highly statistically significant.

SquameScan 850C Skin Angle Quality TesterMeasuring principle
SquameScan 850A generates a circular beam (wavelength=850 nm) that passes through a tape strip containing SC and measures the decrease in light intensity (as a percentage relative to the initial intensity) in an area with a diameter of 13mm. The large area of measurement is a significant advantage, as the uneven distribution of keratinocytes on the tape is balanced. Compared with the measurement at 430nm, the error caused by molecular absorption is basically negligible at the measurement wavelength of 850nm, and thermal denaturation is prevented. When the tape strip is placed on the measuring head, the absorption value will be immediately displayed on the instrument without damaging the sample, allowing for quick and non-destructive reading of the results.

feature

• Keratin quantification: Indirect measurement is achieved by measuring the protein content of the stratum corneum on tape peeling, using infrared light (approximately 850nm) for optical absorption

• Quick measurement: The measurement time for each tape peeling is only a few seconds, saving sample analysis time

• Widely applicable: After peeling off the tape, it can be used for other biological tests, allowing researchers to obtain more information from the same sample. It can be widely used in fields such as dermatology research, cosmetics, and new drug development

• User friendly: compact size, easy to operate

• Data transfer: Equipped with a USB port, data can be transferred to a computer for efficient document recording and data analysis

Technical Specifications

application
1. Analysis of skin barrier function: By measuring the amount of removed stratum corneum, researchers can evaluate the integrity and function of the skin barrier, which is crucial for developing products aimed at improving or maintaining skin barrier health.
2. Penetration research: This device helps evaluate how active ingredients in cosmetics and topical drug formulations penetrate the skin. By analyzing the stratum corneum, researchers can determine the depth and concentration of these ingredients.
3. Efficacy test: it is used to test the effectiveness of various skin care products (such as moisturizing cream and anti-aging face cream), and to evaluate the changes in the cuticle before and after use
4. Safety assessment: SquameScan 850 can be used to ensure that cosmetics do not excessively remove the stratum corneum, thereby avoiding skin irritation or damage.
5. Formula development: The data obtained using Squamescan850 can guide the formulation of new products to ensure that they are both effective and gentle.