GZL150-40L pilot dry granulation machine

NegotiableUpdate on 01/05

Model

Nature of the Manufacturer: Producers

Product Category

Place of Origin

Online Consult

Overview

Production capacity of GZL150-40L pilot dry granulation machine: 5-40kg/h; The Chinese style dry granulation machine is developed based on the absorption of imported models and combined with China's national conditions. It is mainly used in the development and research process of new dosage forms in drug research institutes and for the production of Chinese style preparations, with a minimum feeding amount of 500g. The machine is equipped with an automatic hydraulic system, which adjusts the hydraulic system pressure through sensors and solenoid valves to control the roller pressure and obtain the required density and particle hardness for different drugs. The interface adjustment is convenient and intuitive, and the performance is reliable. The product meets the GMP requirements for drug production.

Product Details

GZL150-40L pilot dry granulation machine

process flow

1. Loading process: The material is intermittently placed into the vertical feeding bin.

2. Vertical feeding process: The dry powder enters the hopper through the feeding port, and under the action of the hollow vertical hinge, the powder is pushed into the horizontal screw feeder. During this process, some gas is discharged from the bottom of the hinge upwards through the hollow part of the hinge, so that the powder can be evenly fed into the horizontal screw feeding port. The feeding amount can be adjusted by frequency conversion to ensure that the screw is fully filled, uniform, not empty or blocked, and the density of the powder is preliminarily improved.

3. Horizontal feeding process: The degassed material enters the horizontal feeder, and through the rotation of the screw, the material is degassed again during the forward movement process, and the high-density material is forcibly fed into the tablet pressing system to complete the pre pressing work.

4. Tablet pressing process: The material after degassing has already reached the pre pressing state before rolling. After pre pressing, the friction between the material entering the bite zone and the surface of the pressure roller is increased, reducing the friction of the material and increasing the bite angle. The material after degassing makes the equipment run more smoothly during the rolling forming process, with uniform strength and stable quality. After forming, the tablet is crushed and granulated in the next process, and the pulverization rate is significantly controlled, ensuring the maximum final quality of the product. Water cooled pressure roller, with external joints, ensures that there is no possibility of water leakage and pollution in the working area, and is easy to clean.

5. Crushing process: The formed tablet is cut into small pieces that are easy to round by a knife toothed crusher.

6. Granulation process: In the granulation system, the crushed material enters the granulator. Under the pressure of the granulator blade, small particles can easily pass through the orifice plate of the granulator without damage, while large particles continue to be crushed into small particles in the granulator, completing the required number of particles for rounding. The whole pellet cutter rotates continuously with high efficiency, and the rotation speed is adjustable by frequency conversion. When the rotation speed of the sieve plate with the same aperture is high, the relative particles are smaller, thus completing the entire production process from dry powder to particles.