Manufacturer of fully automatic drying granulation machine

GF-80ZManufacturer of fully automatic drying granulation machine

Device description

The dry granulation machine is a process in which a mixed powder material (Western medicine or traditional Chinese medicine extract) containing a certain amount of crystal water is poured into a conical hopper, and the material is compressed, degassed, and evenly distributed on the surfaces of two pressure wheels through the downward rotation of an irregular conical screw to generate pre pressure. The material is then bitten into the bite area by two pressure wheels with a certain squeezing thrust, first squeezed into flakes, and then chopped and granulated in the granulation system.

Equipment design features: (* Complies with GMP design requirements)

All rotating shafts are equipped with dual sealing devices.

A feeding device using vertically irregular and non equidistant conical screws.

Reasonable hydraulic system design.

The water circulation cooling of the rolling mill can be achieved through ordinary water cooling or forced cooling with ice water machine.

Reasonable surface design of rolling mill:

Manual and automatic adjustable side seal design.

Reasonable lubrication system design.

Reasonable granulation system design.

PLC control/capable of automatic tracking for pressure detection, with fault alarm prompts and self troubleshooting without stopping the machine.
The entire machine is easy to disassemble and clean, and the sealing structure design inside and outside the hood is reasonable. Waterproof design for electrical box and transmission parts. There is no need to worry about pollution and damage to electrical appliances and equipment during the cleaning process.

Technical parameters of dry granulation machine:
Model GF-80

GF-80ZManufacturer of fully automatic drying granulation machine

The advantages and development trends of dry granulation process in pharmaceutical production:
Powder raw materials extracted from western medicine or traditional Chinese medicine (spray drying, freeze drying) are characterized by different particle sizes, uneven density, poor liquidity and easy layering. Therefore, to solve the characteristics of these materials, a key processing step - granulation - must be passed through in order to smoothly proceed to the next process: ⑴ tablet pressing ⑵ capsule filling ⑶ granule packaging.

Currently, using dry granulation mechanism to solve the above problems is a mainstream trend,
This method utilizes the crystallization water of the material itself and relies on the principle of mechanical extrusion to directly compress, shape, roughly crush, and granulate the raw material powder. It is an energy-saving and energy-saving method that can continuously granulate, with simple and convenient operation and low production costs.

Dry granulation requires less equipment, lower maintenance costs, occupies less space, and has lower production and processing costs compared to wet granulation.
Due to its simpler processing technology compared to wet granulation, dry granulation reduces the need for GMP certification.

Dry rolling granulation has lower energy consumption compared to wet granulation; Granulation does not require the addition of any additives or adhesives; After granulation, the product has uniform particle size; High packing density; Good fluidity; After granulation, it is easy to store and transport, with flying dust and less waste; Easy to control solubility, porosity, and specific surface area; Especially for some drugs that cannot be dissolved in water or alcohol, as well as antibiotics and drugs with strong heat sensitivity that are afraid of heating, traditional Chinese medicine extracts that do not meet the required weight ratio, and cannot add adhesives or excipients, they must be processed through dry granulation technology.