Crushing experimental processing

Crushing experimental processingThe process of crushing traditional Chinese medicine at the cellular level by breaking the cell wall (membrane) of animal (plant) medicinal materials to improve their bioavailability is called micro crushing of traditional Chinese medicine cells. The vast majority of traditional Chinese medicine varieties come from animals (plants). Animal (plant) medicinal materials are composed of cells with multiple functions, including cell wall, cell membrane, cytoplasm, nucleus, etc. The particle size is generally between 10 μ m and 100 μ m, and the medicinal active ingredients mainly exist in the cytoplasm and nucleus. In the intact and undamaged state of cells, effective ingredients can only be utilized after being released through the cell membrane and cell wall. The complete cell membrane and cell wall form resistance to the release of active ingredients, and this resistance increases sharply with the increase of the number of cells in the cell mass. The medicinal active ingredients mainly exist within the cell - between the cytoplasm and the nucleus. Due to the dual effects of the inward resistance of the cell wall (membrane) and the coagulation resistance of cell aggregates (coarse powder), the active ingredients are difficult to release and be absorbed by the body or intestines, which is an important reason for the large and unclear dosage of traditional Chinese medicine. To eliminate this resistance, a micro crushing process should be adopted to break down the cells so that the active ingredients inside the cells can directly contact the solvent. This type of homework is not aimed at fineness, and fineness is only used as a macroscopic detection method, which cannot express the true situation of medicinal powder. Generally speaking, the higher the cell wall breaking rate, the finer its fineness. After breaking through the cell wall, the active ingredients inside the cell are fully exposed (instead of being released through the cell wall [membrane] as before), making the drug more effective. After cell level micro pulverization of drug particles, a small amount of intact cells were observed under electron microscopy

The Dawei ultrafine crusher adopts the following advanced technologies

1. Fully enclosed non graded technology: The fully enclosed multi grinding non screening technology used to preserve the active ingredients effectively avoids phenomena such as segregation and loss of active ingredients, and environmental pollution caused by dust spillage.

2. Compression micro crushing technology: In order to improve the crushing efficiency and effectiveness, high-speed impact force and shear force are used to subject the material to the squeezing, kneading, and tearing effects of the medium in the grinding cylinder, shorten the crushing time, and improve the crushing efficiency; At the same time, due to the fluidized state of the material and the same stress state of each particle, its own viscous effect can form uniformly dispersed and precisely composite particle clusters in the finished product, increase density and improve bioavailability, and enhance micro crushing efficiency and technology.

3. Dynamic optimization technology: a technology that optimizes and adapts according to the different characteristics of materials while ensuring the improvement of micro crushing efficiency and effectiveness.

4. Mechatronics technology: a technology that achieves high performance and level of equipment, reduces manual labor, ensures stable and controllable product quality, and avoids quality instability and pollution caused by excessive manual intervention.

5. Comprehensive automation technology: equipped with single machine multifunctional automation (FMC flexibility), making small-scale drug production as simple as large-scale assembly line production.

6. Purification technology: The Dawei ultrafine grinder series is designed and manufactured strictly in accordance with GMP standards, which can meet the special requirements of pharmaceutical powder equipment.

The Dawei ultrafine grinding series equipment has the following characteristics

The parts in contact with the material are all polished stainless steel, which is a universal material for medical and food machinery (can also be changed to other metal materials according to user requirements), to avoid the mixing of heavy metals such as arsenic, cadmium, mercury, lead, copper, etc.

2. Cleanliness and hygiene: Smooth inner and outer surfaces, versatile use of one machine, reduced pollution, and reduced cleaning workload; The crushing process is fully enclosed without dust spillage, fully improving the working environment, and effective ingredients are not lost.

3. Adopting a composite (transparent) soundproof cover greatly reduces noise.

4. Easy to disassemble (assemble), easy to clean, and easy to change materials. Can be cleaned and disinfected with water, compressed air, alcohol, steam, etc.

5. Easy to operate: Capacity adaptation, ensuring material discharge, easy operation and material replacement.

6. Easy maintenance: compact structure, small footprint, and convenient maintenance.

7. Improving the environment: Fully enclosed operations with dust spillage, no loss of active ingredients, and no generation of drug residues can improve the working environment.

8. Efficiency: Crushing, no residue left. The bidirectional effect of high-speed impact force and shear force shortens the crushing time and improves the crushing efficiency.

9. Broad spectrum adaptation: Suitable for any fibrous, high toughness, high hardness, or moisture content material. For pollen and other sporeszhiMaterials that require breaking the cell wall have a breaking rate of over 98%. Adapt to both dry and wet crushing simultaneously. Water, alcohol, or other liquids can be added during wet crushing.

10. Temperature controllable: Through configuration, micro crushing can be carried out at high temperature, room temperature, and low temperature, which can maintain the original physicochemical properties and active ingredients of the material. Inject cold water into the jacket on the outer wall of the grinding cylinder. The crushing temperature can be controlled by adjusting the temperature and flow rate of the cooling water. Low temperature crushing, the freezing system can reach a low temperature of minus 35 ℃ (low-temperature configuration).

Application of Dawei ultrafine grinding equipment

In addition to being applied in biopharmaceuticals, food, and cosmetics, it is also widely used in various industries related to powder applications, such as building materials (preparation of water slag, fly ash, etc.), chemical industry, metallurgy, environmental protection (brick making from garbage micro powder, etc.), electronics (paddle materials, graphite emulsion, etc.), etc.

Welcome new and old customers to visit the factory and conduct on-site inspectionsCrushing experimental processingTo verify the advanced technology!