Low temperature cell wall breaking machine

NegotiableUpdate on 02/11

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Nature of the Manufacturer: Producers

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Overview

The low-temperature cell wall breaking machine adopts the working principle of vibration crushing. The grinding medium, such as hard material balls, rods or columns, is filled in the grinding cylinder (crushing chamber). The grinding cylinder produces circular vibration in the clockwise and counterclockwise directions as shown in Figure 1 under the action of external excitation force

Product Details

Low temperature cell wall breaking machineprinciple

The Dawei Mechanical Ultra fine Grinding Equipment belongs to the new fourth generation vibration mill. It adopts multiple advanced technologies and applies high-speed impact force and shear force according to the different characteristics of the material, so that the material is subjected to high acceleration impact, friction, compression, cutting and other effects of the medium in the grinding cylinder, and can achieve ideal grinding effect in a short time. The material becomes fluidized during the crushing process, so that each particle has the same stress state, achieving precise mixing (dispersion) effect while crushing. By adjusting parameters such as acceleration, it is possible to achieve operations with the goal of crushing and grinding or precision mixing (blending) as the main objective.

The device adopts the working principle of vibration crushing, filling the grinding medium such as hard material balls, rods or columns in the grinding cylinder (crushing chamber). The grinding cylinder produces circular vibration in the clockwise and counterclockwise directions as shown in Figure 1 under the action of external excitation force. The strong vibration of the grinding cylinder causes the medium inside the grinding cylinder to undergo a throwing motion. Under the action of this throwing motion, each medium produces a rotation in the same direction as the circular vibration. At the same time, the medium group also produces 3-5 low-frequency rotations opposite to the circular vibration. So the medium sometimes disperses and sometimes collides with each other, producing a positive impact force p and a lateral shear force L on the material as shown in Figure 2. The material is finely ground, broken, and crushed under the impact, compression, and shear forces of P and L.

The pulverization operation that improves the bioavailability of traditional Chinese medicine by breaking the cell wall (membrane) of animal (plant) medicinal materials is called traditional Chinese medicine cell level micro pulverization. The vast majority of traditional Chinese medicine varieties come from animals (plants). Animal (plant) medicinal materials are composed of cells with multiple functions, including cell wall, cell membrane, cytoplasm, nucleus, etc. The particle size is generally between 10 μ m and 100 μ m, and the medicinal active ingredients mainly exist in the cytoplasm and nucleus. In the intact and undamaged state of cells, effective ingredients can only be utilized after being released through the cell membrane and cell wall. The complete cell membrane and cell wall form resistance to the release of active ingredients, and this resistance increases sharply with the increase of the number of cells in the cell mass. The medicinal active ingredients mainly exist within the cell - between the cytoplasm and the nucleus. Due to the dual effects of the inward resistance of the cell wall (membrane) and the coagulation resistance of cell aggregates (coarse powder), the active ingredients are difficult to release and be absorbed by the body or intestines, which is an important reason for the large and unclear dosage of traditional Chinese medicine. To eliminate this resistance, a micro crushing process should be adopted to break down the cells so that the active ingredients inside the cells can directly contact the solvent. This type of homework is not aimed at fineness, and fineness is only used as a macroscopic detection method, which cannot express the true situation of medicinal powder. Generally speaking, the higher the cell wall breaking rate, the finer its fineness. After breaking through the cell wall, the active ingredients inside the cell are fully exposed (instead of being released through the cell wall [membrane] as before), making the drug more effective. After the drug particles were finely ground at the cellular level, a small amount of intact cells were observed under electron microscopy.

Low temperature cell wall breaking machineFeatures

1. The parts in contact with the material are all polished stainless steel, which is a universal material for medical and food machinery (can also be changed to other metal materials according to user requirements), to avoid the mixing of heavy metals such as arsenic, cadmium, mercury, lead, copper, etc.
2. Cleanliness and hygiene: Smooth inner and outer surfaces, versatile use of one machine, reduced pollution, and reduced cleaning workload; The crushing process is fully enclosed without dust spillage, fully improving the working environment, and effective ingredients are not lost.

3. Adopting a composite (transparent) soundproof cover greatly reduces noise.

4. Easy to disassemble (assemble), easy to clean, and easy to change materials. Can be cleaned and disinfected with water, compressed air, alcohol, steam, etc.

5. Easy to operate: Capacity adaptation, ensuring material discharge, easy operation and material replacement.

6. Easy maintenance: compact structure, small footprint, and convenient maintenance.

7. Improving the environment: Fully enclosed operation, no dust spillage, no loss of active ingredients, no generation of drug residues, can improve the working environment.

8. Efficiency: Crushing, no residue left. The bidirectional effect of high-speed impact force and shear force shortens the crushing time and improves the crushing efficiency.

9. Broad spectrum adaptation: Suitable for any fibrous, high toughness, high hardness, or moisture content material. Materials that require breaking of cell walls, such as pollen and other spore materials, have a breaking rate of over 98%. Adapt to both dry and wet crushing simultaneously. Water, alcohol, or other liquids can be added during wet crushing.

10. Temperature controllable: Through configuration, micro crushing can be carried out at high temperature, room temperature, and low temperature, which can maintain the original physicochemical properties and active ingredients of the material. Inject cold water into the jacket on the outer wall of the grinding cylinder. The crushing temperature can be controlled by adjusting the temperature and flow rate of the cooling water. Low temperature crushing, the freezing system can reach a low temperature of minus 35 ℃ (low-temperature configuration).

Low temperature cell wall breaking machinepurpose

1. Improving product quality: Through cell level micro grinding, the active ingredients are fully released, resulting in high bioavailability; Under the premise of ensuring, the dosage can be reduced; The quality of the finished product is stable and controllable.

2. Improving the grade of finished products: By using cell level micro grinding, combined with surface modification, particle design, composite or precision coating and other application technologies, it provides an effective means for the reform of traditional Chinese medicine dosage forms towards miniaturization and diversification.

3. Reduce production costs: By using cell level micro pulverization, drug efficacy can be improved (reducing dosage), production processes can be simplified (reducing labor and equipment investment), and the requirements for reducing production costs can be achieved.

4. Increase sales of finished products: Due to the stable and controllable quality of finished products, which are clearly precise, compact, and of high grade.

5. High added value of finished products: By improving the quality of finished products, reducing costs, and increasing sales, the finished products have market competitiveness and high added value, effectively reducing the investment risk of Dahua Micro mechanical cell level micro crushing technology, processes, and equipment, and greatly shortening the investment payback period.