Liquid chromatography-mass spectrometry (LC-MS) instrument

The Waters Micromass Quattro Micro Premier Ultima is a high-performance triple quadrupole liquid chromatography-mass spectrometry system with the following core technical features:

1. Ion transport and sensitivity
Adopting Z-Spray double orthogonal ion source design, combined with Z-interface technology, significantly improves ion transport efficiency and reduces matrix effect interference. The signal-to-noise ratio of 10 pg (m/z 609 → 195) in positive ion mode of electric spray is ≥ 20:1, and the dynamic range is up to10610^6106Can tolerate mobile phases containing 20 mmol/L non-volatile salts. StepWave off-axis focusing technology further increases sensitivity by 5-10 times, and the negative ion mode detection limit can reach the Zeptomole level.

2. Scanning speed and multi-channel analysis
Built in EPCAS high-speed acquisition technology, with a scanning speed of 5000 amu/s, supports synchronous monitoring of 5000 sets of MRM channels in a single operation. Fast polarity switching time ≤ 20 ms, suitable for UPLC narrow peak separation requirements (0.3 minute gradient separation). The T-Wave collision pool combined with linear acceleration technology has an RSD of less than 3% for 3000 consecutive injections.

3. Multi functional ionization and qualitative ability
Standard ESI/APCI dual ionization source, optional ESCi composite ionization source for multi-mode synchronous analysis. Support full scan, sub ion scan, parent ion scan, and neutral loss scan, combined with RADAR technology to synchronously obtain quantitative and qualitative data of target substances. MSn multi-level fragmentation function (up to 10 levels) is suitable for complex metabolite structure analysis.

4. Chromatographic compatibility and applications
Combined with ACQUITY UPLC system, microfluidic interface achieves zero dead volume connection. Typical applications include:

• pharmaceuticalThe quantification limit of plasma drugs is 0.2 pg/mL (RSD<11%)

• environmentThe detection limit of bisphenol A in water is less than 0.1 ng/L

• foodBuilt in MRM database for 600 pesticides, with a pesticide residue recovery rate of 85% -115%.

5. Intelligence and maintenance
MassLynx software integrates the Targeted Lynx quantitative module, reducing method development time by 70%. The EMF system monitors the vacuum degree and ion source status in real-time, extending the maintenance cycle by 80%. The overall volume of the machine is 390 × 587 × 810 mm, and the energy consumption is 30% lower than similar products.

The system, through the collaboration of Z-interface and StepWave technology, has become a device in the field of trace quantitative analysis, especially suitable for ADME screening, clinical diagnosis, and environmental compliance testing.