Triple quadrupole liquid chromatography-mass spectrometer

Waters Quattro UltimaTriple quadrupole liquid chromatography-mass spectrometerIt is a high-performance tandem mass spectrometry system designed for highly sensitive and selective analysis of trace compounds in complex matrices. Its core performance characteristics are as follows:

1. Triple quadrupole liquid chromatography-mass spectrometerMass spectrometry system performance
Adopting a triple quadrupole structure (Q1-Q2), the mass range covers 10-2000 amu, with a scanning speed of up to 5000 amu/s. It supports multiple modes such as full scan, sub ion scan, parent ion scan, and neutral loss scan. In the Dynamic Multi Reaction Monitoring (MRM) mode, up to 5000 target substances can be analyzed in a single run, significantly improving throughput. In terms of sensitivity, the signal-to-noise ratio of 10 pg (m/z 609-195) in positive ion mode of electric spray is ≥ 20:1, and the resolution is 2.5M (PPG2000 standard). The collision pool adopts Z-shaped interface technology, effectively reducing ion loss and improving detection reliability in complex matrices.

2. Triple quadrupole liquid chromatography-mass spectrometerIon source and ionization technology
Standard power distribution spray ionization (ESI), atmospheric pressure chemical ionization (APCI) and composite ionization source (ESCI) support fast switching of positive/negative ions (<20 ms). The ion source adopts a double orthogonal design and is resistant to high salt mobile phases (including non-volatile inorganic salt buffer), making it suitable for the analysis of thermally unstable samples. The unique hinged open close spray chamber design reduces the maintenance time of the ion source to 5 minutes, and the system automatically identifies the interface type and adjusts the parameters.

3. Compatibility of chromatographic systems
Seamless integration with ultra-high performance liquid chromatography (UPLC), using microfluidic technology to achieve zero dead volume connection and avoid chromatographic peak diffusion. The retention time lock (RTL) function ensures that the retention time deviation is less than 0.1% when transferring across instrument methods. Optional 96 bit or 108 bit automatic sampler, supporting high-throughput analysis.

4. Data processing and intelligent functions
MassLynx software provides a data processing platform that has been developed and validated for 20 years. It integrates deconvolution reporting software (DRS) and Target Lynx application management module, supporting rapid qualitative and quantitative analysis. Built in PC communication technology (EPCAS) enables high-speed data acquisition, while also having an early maintenance feedback (EMF) system to monitor the status of key components in real time.

5. Application Fields

• Environmental analysisAccurate quantification of pollutants such as pesticides and perfluorinated compounds in water and soil, with detection limits up to ppt level.

• food safetySupport synchronous analysis of 200 types of pesticide residues, with a recovery rate of 85% to 115%.

• clinical researchScreening for genetic diseases in newborns (such as NeoLynx software), identification of drug metabolites, and discovery of biomarkers.

• pharmaceuticalCompliant with FDA 21CFR Part 11 standards, certified by GLP, suitable for pharmacokinetic and bioequivalence studies.

6. Scalability and Maintenance
The vacuum system uses a 255 L/s molecular turbo pump to achieve working vacuum within 3 minutes. Users can upgrade their CI source on-site or replace it with an efficient EI source, increasing sensitivity by 20 times. Modular design supports method migration from single quadrupole to multi-stage MS/MS, reducing maintenance costs by 80%.

In summary, Quattro Ultima has become a device for ultra trace analysis in fields such as environment, pharmaceuticals, and clinical practice, thanks to its Z-shaped interface's high ion transfer efficiency, 5000 amu/s scanning speed, and intelligent workflow.