Liquid chromatography-mass spectrometry triple quadrupole tandem mass spectrometer

AB Sciex 5500 ™ It is a high-performance triple quadrupole tandem mass spectrometer (LC-MS/MS) developed by AB Sciex, specifically designed for trace analysis in complex matrices. It combines ultra-high sensitivity, fast scanning speed, and quantitative performance, and is widely used in fields such as pharmaceuticals, environmental monitoring, food safety, and clinical research.

Core Technology Highlights

1. QJet ™- 2 Ion Introduction Technology
   By optimizing the vacuum distribution and ion focusing path, the ion transport efficiency is significantly improved, and the sensitivity can reachLow Pick Level (pg/mL)Especially suitable for ultra-low concentration component analysis.

2. Bending LINAC ® Collision chamber
   Innovative axial electric field design accelerates ion transport speed while reducing interference from neutral substances, in combination withAcQuRate ™ Pulse counting detectorThe data reproducibility error is less than 0.05%.

3. eQ ™ Electronic Systems
   supportFast positive and negative ion switching (50 milliseconds)With high-speed MRM scanning (capable of detecting 2500 pairs of ions in a single analysis), it meets high-throughput requirements.

4. Turbo V ™ ion source
   The adaptive flow rate range is wide (50 µ L/min~5 mL/min). The self-cleaning probe design effectively reduces the suppression effect of electric spray and improves long-term stability.

Key performance parameters

• Quality Scope：5~1250 m/z， Covering small to medium molecular weight compounds.

• sensitivityThe detection limit is up to 5 fg (signal-to-noise ratio 57:1), and the dynamic range spans 6 orders of magnitude.

• scanning speed20000 amu/sec (linear ion trap mode), which is 5 times higher than the previous generation.

• software platform：Analyst ® The 1.5 software supports intelligent Scheduled MRM algorithm and can automatically manage over 1000 types of analytes.

Application field

• Pharmaceutical R&DDMPK/ADME research, biomarker validation.

• environmental monitoringDetect pollutants such as pesticides and POPs, in compliance with EPA standards.

• food safetyScreening for veterinary drug residues, toxins, and allergens.

• Clinical Mass SpectrometryTherapeutic drug monitoring (TDM) and metabolomics analysis.

summary

AB Sciex 5500 ™ Achieved through six technological innovations (QJet-2, LINAC collision chamber, etc.)Balance of sensitivity, speed, and reliabilityIts modular design (such as optional ion mobility devices) further expands the application scenarios and becomes the gold standard for quantitative analysis of complex samples.