Single quadrupole liquid chromatography-mass spectrometer

Agilent 1956MSDSingle quadrupole liquid chromatography-mass spectrometerLC/MSD is a high-performance analysis system based on the Agilent 1100 series liquid chromatography module, designed specifically for qualitative and quantitative analysis of trace compounds in complex matrices. Its core performance characteristics are as follows:

1. Agilent 1956MSDSingle quadrupole liquid chromatography-mass spectrometerMass spectrometry system performance
Adopting a single quadrupole mass analyzer with a mass range covering 10-2000 amu and a scanning speed of 2500 amu/s, it supports both full scan (Scan) and selective ion monitoring (SIM) modes. In terms of sensitivity, the signal-to-noise ratio of 1 pg (m/z 609) in ESI positive ion mode is greater than 100:1, and the linear dynamic range is up to10610^6106It is equipped with a right angle spray ion source (90 ° design) to effectively reduce matrix pollution. Combined with a heatable quadrupole (up to 100 ℃) and a tap electron multiplier, it ensures long-term stability (mass axis drift<± 0.1 amu/12h).

2. Agilent 1956MSDSingle quadrupole liquid chromatography-mass spectrometerIon source and ionization technology
The standard distribution spray ionization (ESI) and atmospheric pressure chemical ionization (APCI) dual modes support positive/negative ion switching. The hinged open close spray chamber is designed so that the switching time of the ion source is less than 5 minutes, and the system automatically identifies the interface type and adjusts the parameters. Wide flow adaptability (ESI 1-1000 μ L/min, APCI up to 1000 μ L/min), compatible with high salt mobile phases (salt concentration<20 mmol/L).

3. Chromatography system integration
Combined with Agilent 1100 liquid chromatography, zero dead volume connection is achieved using microfluidic technology (CFT) to avoid the risk of liquid leakage. The high-pressure binary gradient pump has a pressure resistance of 8000 psi, a flow rate accuracy of ≤ 0.07% RSD, and supports dual column temperature control (± 0.2 ℃) for a 30 cm chromatographic column. Optional 125 position automatic sampler, cross contamination<0.004%.

4. Intelligent operation and maintenance
Built in fully automatic tuning system, pre installed tuning solution, no need for manual preparation. Equipped with EMF self diagnostic function, real-time monitoring of key component status and early warning of maintenance requirements. Remote login supports engineers to troubleshoot online, significantly reducing maintenance cycles (such as reducing ion source cleaning frequency by 80%).

5. Data Processing and Application
The MassHunter workstation integrates retention time locking (RTL) and peak purity inspection software, which can automatically align UV and mass spectrometry data and quickly identify co eluted peaks. Suitable for the analysis of pesticide residues (ppb level), drug metabolites, environmental pollutants (such as VOCs), and biomolecules (peptides, proteins). In newborn screening, secondary MS testing can efficiently identify metabolic disorder markers.

6. Scalability and Compliance
Through GLP certification, it supports automatic generation of OQ/PV performance verification reports. Users can upgrade to Nano electric spray source (detection limit up to fmol level) or combine it with capillary electrophoresis to expand ultra trace analysis capability.

In summary, the 1956MSD, with its high sensitivity, low maintenance design, and intelligent workflow, has become an ideal choice in the fields of pharmaceuticals, environmental monitoring, and clinical research, especially for laboratories that need to balance efficiency and regulatory compliance.