Triple and four stage rod liquid chromatography-mass spectrometer

1. Revolutionary sensitivity and anti-interference ability

AB SCIEX 6500+adopts innovative IonDrive ™ System technology achieves sensitivity breakthroughs through three core components:

• IonDrive Turbo V ion sourceEnhanced aerodynamics and optimized heating design, resulting in a 35% increase in ionization efficiency

• IonDrive QJet GuideNew ion introduction technology increases ion transport efficiency by 20 times

• IonDrive HED+detectorThe dynamic range of the pulse counting detector reaches 6 orders of magnitude, and the signal-to-noise ratio of 1pg in MRM mode is ≥ 500000:1

The system is equipped with SelexION+ ™ Differential ion mobility technology (optional) can separate isomers with the same mass to charge ratio, achieving high selectivity detection in complex matrices such as whole blood and food extracts. The quality range covers 5-2000 Da, and the quality stability is better than 0.1 amu/24 hours, without the need for insulation design.

2. Fast scanning and high-throughput analysis

The system has industry level scanning performance:

• scanning speedUp to 20000 Da/s, supporting UHPLC strategy

• Polarity switchingOnly 5 ms is needed to achieve synchronous detection of positive and negative ion modes

• Multi channel detectionA single injection can monitor over 1000 MRM channels, and the dwell time can be shortened to 1 ms

• Level 3 MRM mode50 ppb Ma * * Phosphorus signal-to-noise ratio>100:1 (331>99>71)

Combined with ultra-high performance liquid chromatography (such as Waters ACQUITY UPLC), 600-800 samples can be processed daily, with a CV ≤ 1% for 6 consecutive injections.

3. Innovative hardware and system stability

The system adopts modular design to ensure long-term stable operation:

• All metal flow pathCorrosion resistant design, key components have a lifespan of up to 10 years

• Dual mechanical pump systemPumping speed of 950 L/s, maintaining high vacuum stability

• Intelligent MaintenanceICal automatic calibration function optimizes collision energy and voltage parameters in real-time

• compatibilitySupports multi brand UHPLC systems with a flow rate range of 5 μ L/min to 3 mL/min

4. Multi functional scanning and application areas

Supports multiple scanning modes:

• quantitative analysis：MRM、Scheduled MRM、MRM³

• qualitative analysis: Child ion scan, mother ion scan, neutral loss scan

• special functionCombined with linear ion trap (QTRAP 6500+model), supports MS ³ scanning

The main applications include:

• Pharmaceutical and ClinicalADC drug DAR value analysis, newborn genetic metabolic disease screening

• food safetySimultaneous detection of 200+pesticide residues (compliant with GB 2763)

• environmental monitoring：PFAS、 Detection of new pollutants such as nanoplastics

• research fieldMetabolomics, non covalent protein interactions research

5. Intelligent software and compliance support

Standard Analyst ® The software platform provides:

• Intelligent method developmentSchedule MRM algorithm simplifies the establishment of over 1000 analyte methods

• Database supportA quantitative method library and secondary spectrum database containing over 2000 compounds

• complianceCompliant with FDA 21 CFR Part 11, GMP/GLP requirements

• remote serviceSupport AI function expansion and software upgrade

summary

AB SCIEX 6500+ 以10 times higher sensitivity than the previous generation(IonDrive technology)20000 Da/sec high-speed scanningand6 orders of magnitude dynamic rangeThe performance standards for LC-MS/MS quantitative analysis have been redefined. Its modular design and compatibility with SelexION+technology make it a solution for complex matrix trace analysis. Whether it is a brand new device or a professionally maintained second-hand system (with a cost only 1/4-1/3 of a new machine), it can provide reliable data support for fields such as drug research and development, precision medicine, and environmental monitoring.