In vivo skin Raman analyzer

Exploring the Depth of Skin

Full angle skin probe, easy to reach all parts of the body

The RZ-660 has a flexible and easy to operate skin probe, which can easily touch the skin of various parts of the body without adjusting the position of the subject, and collect Raman spectra of different areas of the skin. The entire spectral range (400-3600 cm-1) can be obtained in one acquisition.

Within reach: No need to move the subject, easily reach all parts of the body

Flexible adaptability: Combined with articulated arms and multifunctional pedals to enhance equipment stability

Good compliance: avoids tedious and uncomfortable position adjustments, ensuring that subjects conduct research in a comfortable, safe, and comfortable environment

Figure 1: RZ-660In vivo skin Raman analyzerEquipped with flexible skin probes, it can freely detect the skin of various parts of the human body

ZhuomorePerformance of

Combining high resolution and 200 μ m mechanical detection depth

High performance optical components and efficient data acquisition technology enable complete and fast analysis with just a single acquisition

Integrated visualization camera, capable of simultaneous microscopic image observation and spectral acquisition

A concise and intelligent analysis program

Guided navigation interface: a concise, practical, and user-friendly analysis application that provides guided guidance at every step from subject registration to obtaining comprehensive analysis data, helping you easily complete the entire process

Data Fusion Analysis: An intelligent data processing system that helps you integrate multidimensional evaluation results such as visual, biological mechanisms, and chemical assessments, providing you with multi-dimensional insights into your skin

Deep Data Interpretation: Help you analyze and interpret various complex data in depth, extract clear and practical key information

Figure 2: RZ-660In vivo skin Raman analyzerAn application with concise and intelligent features

Skin analysis methods

RZ-660 can be used to evaluate product penetration and surface deposition, stratum corneum thickness, skin barrier, skin hydration and moisture content, lipid conformation and arrangement, natural moisturizing factor (NMF) distribution, product/skin interaction, sunscreen efficacy, etc., to assist in the development of topical products.

Now, convince your consumers with scientific, intuitive, and easy to read test results, and face the challenges of contemporary product development and marketing!

01. Skin moisture content test

Accurately understanding the moisture content and depth distribution of the skin can help you optimize formulas, develop products using real-time moisture content data, and improve product efficacy. By using the matching software, the results can be converted into easily interpretable Raman thermograms with simple operations, making it easier for your consumers to understand and believe in the efficacy of the product.

Figure 3: Distribution of skin moisture content of subjects with depth and its conversion into Raman thermogram

02. Assessment of stratum corneum thickness

The skin moisture depth distribution curve with micrometer level accuracy can be used to evaluate the thickness of the stratum corneum and comprehensively understand the skin structure.

Figure 4: Calculation of stratum corneum thickness - Fit two lines based on the measured water concentration curve, and the intersection of the two lines is the lower boundary of the stratum corneum

03. Lipid conformation and skin distribution

Characterizing the lipid conformation and depth distribution of the skin can be used to analyze the arrangement and composition of lipids within the skin barrier, helping to optimize cosmetic formulations aimed at "moisturizing repair", enhancing their moisturizing ability, and protecting the skin barrier.

Figure 5: Changes in lipid conformation of five volunteers with skin depth

04. Lipid content and skin distribution

Characterizing the lipid content and depth distribution of the skin can help develop products aimed at "maintaining stability," "sensitive skin," and "anti-aging," reducing skin irritation and improving skin elasticity and firmness.

Figure 6: Changes in lipid content of five volunteers with skin depth

05. Skin penetration of active molecules

RZ-660 can be used to analyze the penetration of active ingredients on the skin surface. This experiment selected the popular star active ingredient (nicotinamide) available on the marketRetinolSunscreen samples were applied to the skin surface of the subjects, and Raman spectra of human skin were collected using RZ-660 after 4 hours of application. The following figure shows that the nicotinamide sample mainly stays in the stratum corneum, while retinol remainsThe sample can penetrate through the stratum corneum, while sunscreen cannot penetrate through the stratum corneum.

Figure 7: Skin penetration map of active ingredients